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ZVI ZADIK, LUICE DE. LACERDA, AVINOAM KOWARSKI, Evaluation of the 6-Hour Integrated Concentration of Cortisol as a Diagnostic Procedure for Cushing’s Syndrome, The Journal of Clinical Endocrinology & Metabolism, Volume 54, Issue 5, 1 May 1982, Pages 1072–1074, https://doi.org/10.1210/jcem-54-5-1072
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Abstract
The diagnostic value of the 24-h integrated concentration (IC) test of cortisol (IC-24-F) was found to be superior to the value of both urinary 17OHCS and urinary free cortisol tests. The IC-24-F test is too cumbersome for widespread clinical use. The purpose of the present study was to evaluate the diagnostic value of an abbreviated and practical 6-h IC of cortisol (IC-6-F) test.
The IC of cortisol (IC-F) was measured in 68 normal subjects and 13 patients with surgically proven Cushing’s syndrome. A portable nonthrombogenic constant blood withdrawal system was used over a 24-h period. The IC-F was measured in plasma withdrawn during each ½-h period (IC-½-F).
The mean of 12 consecutive measurements of IC-½-F yielded the IC-6-F. The mean of all the IC-½-F collected over a 24-h period constituted the IC-24-F.
The IC-½-F of the patients and their IC-6-F from 0800-1400 h, 1400-2000 h, and 2000-0200 h overlapped the corresponding levels in the control subjects. There was no overlap between the IC-24-F and the IC-6-F (from 2000-0200 h) of the patients and the control subjects.
It was concluded that the diagnostic value of a 6-h IC-F testconducted during the afternoon and early part of the night is equal to the diagnostic value of the 24-h IC-F test. (J Clin Endocrinol Metab54: 1072,1982)