-
Views
-
Cite
Cite
GEORGE R. MERRIAM, DAVID D. BRANDON, SHINZO KONO, S. EDWARD DAVIS, D. LYNN LORIAUX, MORTIMER B. LIPSETT, RAPID METABOLIC CLEARANCE OF THE CATECHOL ESTROGEN 2-HYDROXYESTRONE, The Journal of Clinical Endocrinology & Metabolism, Volume 51, Issue 5, 1 November 1980, Pages 1211–1213, https://doi.org/10.1210/jcem-51-5-1211
- Share Icon Share
Abstract
The plasma metabolic clearance rate (MCRp) of 2-hydroxyestrone was measured in normal young adults by two methods: infusion of unlabeled 2-OHE1 to equilibrium with radioimmunoassay of plasma 2-OHE1 levels, and infusion of [3H]2-OHE1 to equilibrium with measurement of chromatographically purified plasma [3H]2-OHE1. MCR′s were 40–70,000 L/day and 15–50,000 L/day, respectively. This is the highest known MCR for a naturally occurring steroid. The only measurable plasma metabolite of [3H]2-0HE1, co-migrated with 2-methoxyestrone. When [3H]2-0HE1 was incubated with blood samples in vitro, [3H]ξ-methoxyestrone was rapidly formed. Since this MCR is higher than cardiac output, clearance must occur primarily in the blood compartment, probably largely by the action of erythrocyte catechol–0–methyltransferase.