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ARIEL BARKAN, RAPHAEL MARILUS, GIDEON WINKELSBERG, DANIEL YESHURUN, ILANA BLUM, Primary Hyperparathyroidism: Possible Cause of Primary Hyperaldosteronism in a 60-Year-Old Woman, The Journal of Clinical Endocrinology & Metabolism, Volume 51, Issue 1, 1 July 1980, Pages 144–147, https://doi.org/10.1210/jcem-51-1-144
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Abstract
Hypertension and hypokalemia were found in a 60-yr-old woman suffering from primary hyperparathyroidism. Laboratory investigations in this patient disclosed 1) elevated levels of plasma aldosterone (PA) which could not be suppressed by a high sodium diet alone or in combination with fludrocortisone (Florinef); 2) a decline of the elevated PA levels after 4 h of ambulation; and 3) low PRA which was unresponsive to stimulation by a low sodium diet coupled with diuretic-induced volume depletion and 4 h of ambulation. These findings were consistent with the diagnosis of primary hyperaldosteronism. Extirpation of a parathyroid adenoma reduced the patient's serum calcium level to normal, and subsequently, a normalization of her blood pressure, serum electrolytes, PA, and PRA were observed. On the basis of these data it is suggested that in this case hyperaldosteronism may have been caused directly or indirectly by primary hyperparathyroidism.
