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J. R. GIVENS, E WIEDEMANN, RN ANDERSEN, AE KITABCHI, β-ENDORPHIN AND β-LIPOTROPIN PLASMA LEVELS IN HIRSUTE WOMEN: CORRELATION WITH BODY WEIGHT, The Journal of Clinical Endocrinology & Metabolism, Volume 50, Issue 5, 1 May 1980, Pages 975–976, https://doi.org/10.1210/jcem-50-5-975
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Abstract
Based on the findings of elevated circulating β-endorphin (β-END) levels in genetically obese (fa/fa) rats and the reversal of the overeating of genetically obese (ob/ob) mice by naloxone, circulating βEND and β-lipotropin (β-LPH) levels were measured in 8 hirsute, hyperandrogenic, oligo-amenorrheic women of varying weights. Circulating β-END and β-LPH levels were significantly elevated (p<.001) above the levels in nonobese control subjects and were positively correlated with body weight (p<.025). Based on these data and indirect evidence inthe literature, we propose a role may exist for β-END and/or β-LPH in human obesity and in adrenal androgen secretion.