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CARLENE W. ELSNER, JOHN E. BUSTER, DALE L. PRESTON, ALLEN P. KILLAM, Interrelationships of Circulating Maternal Steroid Concentrations in Third Trimester Pregnancies. III. Effect of Intravenous Cortisol Infusion on Maternal Concentrations of Estriol, 16α-Hydroxyprogesterone, 17α-Hydroxyprogesterone, Progesterone, 20α-Dihydroprogesterone, Δ5-Pregnenolone, Δ5-Pregnenolone Sulfate, Dehydroepiandrosterone Sulfate, and Cortisol, The Journal of Clinical Endocrinology & Metabolism, Volume 49, Issue 1, 1 July 1979, Pages 30–33, https://doi.org/10.1210/jcem-49-1-30
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Abstract
The effect of a large dose (1000 mg) of iv cortisolhemisuccinate on circulating steroid concentrations in five women, 28–34 weeks gestational age, is reported. Maternal concentrations of estriol, 16α-hydroxyprogesterone, 17α-hydroxyprogesterone, progesterone, 20α-dihydroprogesterone, △5-pregnenolone, △5-pregnenolone sulfate, dehydroepiandrosterone sulfate, and cortisol were measured by RIA before and at 8 and 12 h after iv cortisol infusions at 0 and 8 h. Data were evaluated by repeated measure analysis of variance. Estriol and 17α-hydroxyprogesterone suppressed initially (P ¼ 0.05) and suppressed further with retreatment and increased treatment time (P ¼ 0.05). Dehydroepiandrosterone sulfate and progesterone suppressed initially (P 0.05) but did not suppress further with retreatment and increased treatment time (P > 0.05). △5-Pregnenolone and △5-pregnenolone sulfate increased initially (P ¼ 0.05) but did not increase further (P > 0.05). Concentrations of 16α-hydroxyprogesterone and 20α-dihydroprogesterone were unchanged by cortisol infusion initially (P > 0.1) and with retreatment and increased treatment time (P > 0.1).