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R. BOUILLON, J. REYNAERT, J. H. CLAES, W. LISSENS, P. DE MOOR, The Effect of Anticonvulsant Therapy on Serum Levels of 25-Hydroxy-Vitamin D, Calcium, and Parathyroid Hormone, The Journal of Clinical Endocrinology & Metabolism, Volume 41, Issue 6, 1 December 1975, Pages 1130–1135, https://doi.org/10.1210/jcem-41-6-1130
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Abstract
In 20 female patients treated for 2 to 37 years (mean :12) with anticonvulsant drags, low serum levels of 25-hydroxy-vitamin D (25-OH-D; 6.4 ± 3.2 ng/ml M ± sd), relative hypocalcemia (9.2 ± 0.4 mg/100 ml) and high levels of parathyroid hormone (PTH 277 ± 165 pg/ml) were found compared to an age-matched control group (respectively 8.6 ± 3.2 ng/ml, 9.6 ± 0.3 mg/100 ml and 183 ± 95 pg/ml) living in the same psychiatric clinic.
A significant negative correlation was found between total duration of treatment and either serum 25-OH-D or serum calcium.
After treatment with an oral vitamin D3 supplement (2000 IU/day) for 3 weeks, the serum 25-OH-D levels, although increased, remained lower than normal in the epileptic group and neither their hypocalcemia nor their secondary hyperparathyroidism were corrected.
These data confirm the occurrence of vitamin D deficiency in patients treated with anticonvulsant drugs resulting in hypocalcemia and secondary hyperparathyroidism.