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KAMALA S. JAYA RAO, N. RAGHURAMULU, Insulin Secretion in Kwashiorkor, The Journal of Clinical Endocrinology & Metabolism, Volume 35, Issue 1, 1 July 1972, Pages 63–66, https://doi.org/10.1210/jcem-35-1-63
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ABSTRACT
Basal plasma insulin levels were normal in kwashiorkor, but their response to oral glucose was impaired. As a result of the impaired insulin secretion, the glucose tolerance was abnormal and there was no reduction in plasma α-amino nitrogen levels. It is suggested that the inability of the P-cells to respond to an acute stimulus may reflect a breakdown of the adaptation mechanism to the stress of protein-calorie malnutrition, which may be the basis of the clinical evolution of kwashiorkor.
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Copyright © 1972 by The Endocrine Society
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