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A. DAZORD, J. SAEZ, J. BERTRAND, Metabolic Clearance Rates and Interconversion of Cortisol and Cortisone, The Journal of Clinical Endocrinology & Metabolism, Volume 35, Issue 1, 1 July 1972, Pages 24–34, https://doi.org/10.1210/jcem-35-1-24
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ABSTRACT
Nine normal subjects (four men and five women), three patients with Cushing's syndrome, and three hyperthyroid females were given a constant infusion of 3H-cortisol and 14C-cortisone. In normal subjects the MCR of cortisone, 451 ± 79 (sd) L/m2/24 hr, was significantly greater than the MCR of cortisol, 155 ± 40 (sd) L/m2/24 hr. Both these clearances were increased in Cushing's syndrome and hyperthyroidism.
In the normal subjects, the transfer constant measuring the conversion of cortisone into cortisol (ρ) EFBB 85 ± 8.5 (sd)% was significantly greater than that measuring the conversion of cortisol into cortisone (ρ) FEBB 60 ± 4.6 (sd)%, and was decreased in hyperthyroidism explaining the augmented urinary THE.
The measurement of the rate of production and secretion of cortisol and cortisone by this method was shown to be impossible as evidenced by paradoxical results. The absence of a steady state in the production of cortisol did not appear to be the only cause of difficulty. The possibility that, when the production of F is high there will be a non-homogeneous mixture of radioactive and endogenous F, is discussed. This could explain the differences in specific activities observed in the urinary procedure for secretion of cortisol.
The simultaneous measurement of cortisol and cortisone in the adrenal and peripheral venous blood in two patients, demonstrated higher concentrations of cortisone in the adrenal venous blood suggesting cortisone was secreted.
