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MORRIS SCHAMBELAN, EDWARD G. BIGLIERI, Deoxycorticosterone Production and Regulation in Man, The Journal of Clinical Endocrinology & Metabolism, Volume 34, Issue 4, 1 April 1972, Pages 695–703, https://doi.org/10.1210/jcem-34-4-695
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Abstract
Secretory rates of deoxycorticosterone(DOC) and urinary excretion of tetrahydro-DOC (THDOC) were determined in normal subjects. Mean THDOC excretion (n = 15) was 24 ± 2.4 μg/24 hr and DOC secretion (n = 26) was 164 ± 22.3 μg/24 hr. The mean metabolic clearance rate by either the single injection or the constant infusion technique was 956 ± 69 1/24 hr in three normal subjects, with higher values noted in a patient with hyperthyroidism and one patient with primary aldosteronism. Plasma disappearance t1/2 (n = 2) averaged 70 min, and estimated plasma concentration (n = 3) was 26.0 ± 5.9 mμg/100 ml.
Factors that control DOC production were examined in normal subjects and patients with panhypopituitarism. Urinary THDOC increased five-fold in response to ACTH infusion (n = 6) and decreased 50% when ACTH was suppressed by dexamethasone (n = 7), whereas aldosterone excretion responded to a lesser extent. THDOC also increased promptly after ACTH infusion in one patient with panhypopituitarism, compared to a delayed and reduced response of 17-hydroxycorticoids. When the pituitary-adrenal axis was intact, manipulation of the renin-angiotensin system by salt restriction (n = 4), angiotensin infusion (n = 4) or production of mineralocorticoid escape (n = 3) had no significant effect on urinary THDOC, in marked contrast to the effect on aldosterone excretion in these subjects. However, in two patients with panhypopituitarism and in a normal subject receiving dexamethasone for 13 days, salt restriction resulted in increased THDOC excretion, which was further augmented in the normal subject by angiotensin infusion.
These studies suggest that DOC is primarily an ACTH-dependent steroid but that under certain conditions, a modifying effect of the reninangiotensin system can be demonstrated.
