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KENNETH T. KIRTON, GORDON G. NISWENDER, A. RESS MIDGLEY, ROBERT B. JAFFE, ADELBERT D. FORBES, Serum Luteinizing Hormone and Progesterone Concentration During the Menstrual Cycle of the Rhesus Monkey, The Journal of Clinical Endocrinology & Metabolism, Volume 30, Issue 1, 1 January 1970, Pages 105–110, https://doi.org/10.1210/jcem-30-1-105
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Abstract
Concentrations of luteinizing hormone (LH) and progesterone were determined in peripheral serum samples obtained daily through 4 menstrual cycles in 4 rhesus (Macaca mulatto) monkeys. The incidence and time of ovulation was determined by laparoscopic examination. Progesterone was assayed by a competitive protein-binding method and LH by a radioimmunoassay for ovine LH which was shown to be capable of measuring simian LH. LH levels were similar during the follicular and luteal phases of the cycle, and rose sharply to approximately a 10-fold increase in concentration at midcycle in 3 of the 4 animals. All 4 cycles were ovulatory as determined by luteal progesterone concentrations and by laparoscopic examination. The data suggest that either the 24-hr sampling interval was not frequent enough to detect the LH peak in the fourth animal, or that ovulation occurred in the absence of an LH rise. In no case was ovulation observed to occur nor did progesterone concentration rise prior to the surge of LH. Ovulation occurred within 30 hr after the peak concentration of LH in 3 of the animals. Ten or 12 serum samples were obtained at 8-hr intervals near the time of ovulation in 3 additional animals. Plasma progesterone concentration increased slightly with the LH surge, plateaued or decreased slightly near the time of ovulation, and then increased markedly with functional development of the corpus luteum.
