-
Views
-
Cite
Cite
GERALDO A. MEDEIROS-NETO, EDUARDO MANZANO, A. B. ULHOA CINTRA, Intrathoracic Goiter in a Euthyroid Patient: Localization with 125I and Study of Thyroidal Iodoproteins, The Journal of Clinical Endocrinology & Metabolism, Volume 29, Issue 2, 1 February 1969, Pages 183–190, https://doi.org/10.1210/jcem-29-2-183
- Share Icon Share
Abstract
A patient with a large intrathoracic goiter and an iodinated albumin-like protein in the plasma was studied. This protein represented 6.3% of the total plasma iodine 2 hr after the tracer dose and rose to almost half of the total plasma radioactivity after 48 hr. It remained at this same level even after 15 days. The half-life of the iodinated protein was calculated to be 28 days (K =0.025) with a distribution volume of 4.7 liters. The thyroid obtained after surgery was a hyperplastic goiter with a considerable degree of follicular hyperplasia and several anomalies in shape and size of the cells. Particulate iodoprotein was present in a higher proportion as compared with normal thyroid tissue. The results obtained with the radioactive tracer (12.5–17.1% of the total iodine) and with stable iodine (17.8–21.0% of the total) were almost the same. The particulate iodoprotein was difficult to hydrolyze completely and yielded only 5% iodothyronines (T3+T4). Thyroglobulin was identified in the soluble fraction (100,000×g) but constituted less than half of the total soluble 125I-radioactivity. The possibility that these abnormalities may constitute an inborn defect in protein biosynthesis is discussed.