Abstract

The cortisol binding affinity (CBA) of plasma transcortin was measured in more than 400 individual plasmas by means of competitive adsorption with fuller's earth. Within the limits of precision of the method no within-person variation in CBA was detected. More specifically, the CBA did not change during pregnancy or estrogen treatment. Between-person variations in CBA were looked for in both a normal Belgian and a normal Sardinian population; again no differences were found. The apparent association constant obtained here in whole plasma is the same as that described for isolated transcortin.

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