Abstract

Following the administration of randomly tritiated 19-hydroxy-δ4-androstene-3,17-dione to 2 young men, about a dozen neutral metabolites were isolated from their urine. One of these was identified as the unchanged precursor. The chromatographic behavior of several other metabolites suggests that they may have unusual structures. In addition, radioactive estrone was isolated from both urines and identified by isotopic dilution analysis. The presence of estriol in one of the urines was also demonstrated. About 0.03% of the tritium administered was isolated as estrone.

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