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WILLIAM G. KELLY, SIEGRUN R. RANUCCI, On the Metabolism of 19-Hydroxy-Δ4-androstene-3,17-dione. Conversion to Urinary Phenolic and Neutral Metabolites in Men, The Journal of Clinical Endocrinology & Metabolism, Volume 28, Issue 10, 1 October 1968, Pages 1401–1411, https://doi.org/10.1210/jcem-28-10-1401
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Abstract
Following the administration of randomly tritiated 19-hydroxy-δ4-androstene-3,17-dione to 2 young men, about a dozen neutral metabolites were isolated from their urine. One of these was identified as the unchanged precursor. The chromatographic behavior of several other metabolites suggests that they may have unusual structures. In addition, radioactive estrone was isolated from both urines and identified by isotopic dilution analysis. The presence of estriol in one of the urines was also demonstrated. About 0.03% of the tritium administered was isolated as estrone.