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D. A. KOUTRAS, C. N. TASSOPOULOS, S. MARKETOS, Endemic Goiter in Greece: Salivary Iodide Clearance in Goitrous and Nongoitrous Persons, The Journal of Clinical Endocrinology & Metabolism, Volume 27, Issue 6, 1 June 1967, Pages 783–788, https://doi.org/10.1210/jcem-27-6-783
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Abstract
The mixed salivary iodide clearance rate (Sal. 131I CI.), the salivary flow and the saliva/plasma (S/P) ratio of iodide were measured in 30 patients with endemic goiter, 17 nongoitrous inhabitants of the endemic areas, 50 “normal” persons from non-endemic areas, 20 hyper- and 9 hypothyroid patients. A significant inverse relation between salivary flow and S/P ratio was found. The nongoitrous persons from the endemic areas had significantly higher salivary flow and Sal. 131I Cl. values than the patients with endemic goiter or the normal controls. There was no significant difference in the S/P ratio. It is suggested that the finding of a higher Sal. 131I CI. (or, expressed otherwise, of a similar S/P ratio in spite of a higher salivary flow) provides evidence for a more efficient salivary iodide trap in the nongoitrous inhabitants of the endemic areas. In view of the similarities between the salivary and the thyroid glands, this provides indirect evidence for the hypothesis that the nongoitrous persons possess a more efficient thyroidal iodide trap and hence compensate for the environmental iodine deficiency by increasing the thyroidal iodide clearance rate without significant enlargement of the thyroid gland.