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ROSE H. PARKER, WILLIAM H. BEIERWALTES, Iodine Repletion After Iodine Deficiency, The Journal of Clinical Endocrinology & Metabolism, Volume 23, Issue 6, 1 June 1963, Pages 568–573, https://doi.org/10.1210/jcem-23-6-568
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Reports from this laboratory have described studies over a period of 2 years with a nongoitrous, euthyroid, iodine-deficient population exhibiting elevated serum proteinbound iodine (PBI) values with normal serum butanol-extractable (BEI) values. The suggestion was made that the PBI elevation might be related to release of nonmetabolically active iodoprotein under increased TSH stimulation associated with iodine deficiency. If this were so, the increased PBI-BEI difference would be expected to decrease with iodine repletion and decrease of elevated thyroidal I131 uptake values.
Accordingly, the effect of iodized salt was investigated in 20 of these subjects who had been exposed to iodine deficiency for an average period of 8 years. Ten received iodized salt only, 5 received an additional supplement of 180 mg desiccated thyroid daily, and 5 were given a daily supplement of iodine as KI alculated to equal the iodine in the thyroid medication. Urinary iodine excretion rose from a mean of 36 μg/day to 555 μg/day in the group on iodized salt alone, and to 866 μg/day in the group on the 360 μg/day supplement of iodine from KI. A more rapid rise in urinary iodine excretion in the third group given desiccated thyroid supplements correlated with the faster and greater simultaneous suppression of elevated thyroidal 24-hr I131 uptakes from a mean of 45.5% before to 6 % after, as compared to a final level of 15.4% in the 2 groups not given desiccated thyroid. Although both the serum PBI and BEI values rose during the first 54 days of the use of iodized salt from a mean of 8.2 to 13.7 μg/100 ml, and from a mean of 5.5 to 7.7 μg/100 ml, respectively, the serum PBI and BEI values decreased to normal and the PBI-BEI difference diminished significantly from an initial level of 2.7 μg/100 ml to a level of 1.4 μg/100 ml by 180 days in the 2 groups not receiving desiccated thyroid supplements. The temporal association with iodine repletion of an increasing urinary iodine excretion, decreasing thyroidal I131 uptake, and a decreasing serum PBI and serum PBI-BEI difference is compatible with our previous suggestion that the increased PBI-BEI difference was composed of a nonmetabolically active iodoprotein released from the thyroid gland under increased TSH stimulation associated with the iodinedeficient state.
