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W. H. Perloff, Influence of Testerone Propionate on the Size of Uterine Fibroids in Human Male, The Journal of Clinical Endocrinology & Metabolism, Volume 2, Issue 6, 1 June 1942, Page 419, https://doi.org/10.1210/jcem-2-6-419
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Abstract
In a Previous communication we were able to demonstrate that small pellets of estradiol benzoate implanted locally into the uterus of guinea pigs produce fibromyomatous tumors in 75 per cent of the animals used. It appeared that androgen implanted simultaneously has a tendency to limit the extent to which the estrogen is able to produce these tumors. In order to determine whether androgen had comparable depressing effects on fibromyonatous tumors in the human female we decided to treat patients having fibroids with testosterone propionate.
This effect has been reported by various workers in the treatment of metrorrhagia in patients in whom fibroid tumors were found to be present. Opinion varies as to the efficacy of this mode of treatment and there are few observations concerning changes in the size of these tumors.
In view of the fact that we will not be able to continue this work further, I would like to report 3 cases in whom testosterone propionate was employed and in whom we were particularly concerned with changes in the size of the uterine fibroids.