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George Levene, Lois C. Miller, Acromegalic Gigantism without Cardiac Enlargement: Report of a Case, The Journal of Clinical Endocrinology & Metabolism, Volume 2, Issue 6, 1 June 1942, Pages 403–405, https://doi.org/10.1210/jcem-2-6-403
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Abstract
Acromegaly is usually associated with skeletal overgrowth and splanchnomegaly. Most observers regard cardiac enlargement as an essential feature of the disease.
The causative factor in the production of enlargement of the heart has been variously ascribed to a), direct hormonal activity (1); b), degenerative changes in the arterial vascular system (2); c), compensatory hypertrophy in response to the ever increasing demands of disproportionately rapid overgrowth of the body (3); and d), to alteration in the shape of the cavity of the chest (4).
Cameron (5) stated that the organs enlarge, especially the heart. Cecil (6), Goldgieher (7), MacCallum (8), Sternberg (9), Marie and Souza-Leite (10), and others, believed that the heart participates in the general somatic and visceral enlargement. Englebach (11) stated that ‘the heart is enlarged proportionately to the body growth.’
Hinsdale (2) described the changes in the heart as a true sclerotic myocarditis.