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C. D. Davis, E. C. Hamblen, W. Kenneth Cuyler, Margaret Baptist, Progesterone Therapy and Progestin Metabolism in Abortion, The Journal of Clinical Endocrinology & Metabolism, Volume 2, Issue 6, 1 June 1942, Pages 377–382, https://doi.org/10.1210/jcem-2-6-377
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Abstract
The council on pharmacy and chemistry of the American Medical Association recently stated: ‘It is indeed difficult to conclude from the available data whether or not progesterone or active corpus luteum extracts are of value in the treatment of habitual and threatened abortion’ (1). The accurate evaluation of therapy, of necessity, must remain difficult until we have a better understanding of the etiologic factors in abortion.
Diagnosis of threatened abortion has been rendered uncertain by the fact that biologically active prc gestin is identified in human tissues and fluids in only small quantities by the present methods of bioassay. Some of the more recent and more sensitive of these methods have not been applied to clinical studies.
Venning's (2) method for the determination of pregnanediol, an excretion product of progestin metabolism, aroused much enthusiasm. It was hoped that, at last, there was a diagnostic implement by which significant alterations in intrinsic progestin levels might be determined.
