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Udall J. Salmon, Samuel H. Geist, A. Austin Salmon, Irving L. Frank, A Six-hour Pregnancy Test, The Journal of Clinical Endocrinology & Metabolism, Volume 2, Issue 3, 1 March 1942, Pages 167–170, https://doi.org/10.1210/jcem-2-3-167
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Abstract
The work reported here had its origin in a series of studies designed to determine how soon after the administration of gonadotropic hormone, gonadatropic effects could be detected in the immature rat ovary. In a study of the time factor relationship of follicle stimulation to luteinization in the immature rat, several years ago, it was noted that “in somea cses the immature rat ovary will respond to gonadotropic hormone with a follicle-Stimulating reaction as early as 26 hours after the first injection” (1). In subsequent studies an attempt was made to determine whether it was possible, by increasing the dosage of the gonadotropin, adding hypophyseal synergist or using older animals, to accelerate the gonadotropic action of the extracts. Two observations were made during these studies which suggested their utilization as a test for human pregnancy. These observations are that, a), as early as 6 hours after the administration of pregnancy urine to immature rats, one can detect marked hyperemia of the ovaries, and, b), by the end of 24 hours one can discern gross and microscopic evidence of estrogenic stimulation of the vagina.
