Abstract

An intelligent therapeutic approach to the problem of menometrorrhagia will result only when the mechanism of uterine bleeding is fully understood. The artificial induction of pseudomenstrual bleeding in the castrated human female clarifies many controversial points. The data on the case to be reported has been charted in figure 1.

case report

Z.M.D., a white female, 28 years of age, presented hep self at the Endocrine clinic of the University Hospital during the latter part of 1939 complaining of severe menopausal symptoms. One year previously she had been submitted to laparotomy and both fallopian tubes and ovaries were removed because of tubo-ovarian abscesses. From Nov. 14 to 16, 1939, a 48-hour urine specimen was obtained and the urine was found to contain an insufficient amount of estrogen for assay. The vaginal smear revealed a castrate or 1, + reaction. A curettage was performed on Nov. 16, 1939 and no endometrium could be obtained.

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