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P. CZERNIAK, A. HARELL-STEINBERG, THE CHRONOLOGY OF EVENTS IN THE DEVELOPMENT OF SUBACUTE THYROIDITIS, STUDIED BY RADIOACTIVE IODINE, The Journal of Clinical Endocrinology & Metabolism, Volume 17, Issue 12, 1 December 1957, Pages 1448–1453, https://doi.org/10.1210/jcem-17-12-1448
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Abstract
THE clinical picture of subacute thyroiditis was described in 1904 by De Quervain (1). Since then, and especially in the last ten to fifteen years, there has been an increasing number of reports of this disease in the medical literature, with histologic studies and clinical observations (2–4). However, most of the problems of subacute thyroiditis have remained unsolved; its etiology is still unknown and the therapeutic approach is empiric.
Lately, radioactive iodine (I131) has proved to be a useful tool in the investigation of this disease. Attention has been drawn (5–9) to the fact that the thyroidal uptake of I131 in subacute thyroiditis is low despite a clinical picture frequently presenting numerous signs of hyperthyroidism, often including high levels of serum protein-bound iodine.
Using these observations as a basis, we studied 10 patients over a prolonged period of time. They were subjected to repeated I131 tests (10), the first being performed between the tenth and sixtieth day following the appearance of first symptoms. The tests were repeated every fifteen to thirty days during the first two months of illness, and then at intervals of two to four months.
