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JOHN B. STANBURY, J. W. A. MEIJER, A. A. H. KASSENAAR, THE METABOLISM OF IODOTYROSINES. II THE METABOLISM OF MONO- AND DI-IODOTYROSINE II CERTAIN PATIENTS WITH FAMILIAL GOITER, The Journal of Clinical Endocrinology & Metabolism, Volume 16, Issue 7, 1 July 1956, Pages 848–868, https://doi.org/10.1210/jcem-16-7-848
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When I131-labeled dl-di-iodotyrosine (T2*) is injected intravenously into patients with treated myxedema (1) or into normal subjects (2), labeled iodine which appears in the urine is almost entirely inorganic iodide. Only a small fraction of the administered T2* escapes deiodination. I131-labeled l-mono-iodotyrosine (T1*) is similarly deiodinated; but in the case of labeled d-mono-iodotyrosine, a large fraction appears unchanged in the urine.
After ingestion or injection of I131, very little (3) if any (4, 5) labeled free mono- or di-iodotyrosine appears in the serum. Recently both labeled mono-and di-iodotyrosine were detected in large amounts in the serum of a patient with hypothyroidism and familial goiter (6). One possible explanation for this unusual finding was that degradation of these substances might be defective.