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I. S. FRIEDMAN, A. MACKLES, I. DAICHMAN, DEVELOPMENT OF VIRILIZATION DURING PREGNANCY, The Journal of Clinical Endocrinology & Metabolism, Volume 15, Issue 10, 1 October 1955, Pages 1281–1290, https://doi.org/10.1210/jcem-15-10-1281
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Abstract
THE onset of masculinization during pregnancy is extremely rare. JL Javert and Finn reviewed reports of 122 arrhenoblastomas and found 4 instances in which the onset of symptoms coincided with pregnancy (1). These were cases reported by Felicissimo Paula Xavier and deAbreu Junqueira (2), by Brentnall (3) by Searle, Haines and Baker (4), and later by Falk and Mason (5). The patient in the report by Searle et al. had an “adrenal-like” tumor removed, but the other tumors were listed as arrhenoblastomas.
Further instances of the onset of virilization during pregnancy have been published by Baird and Astwood (6), by Culiner and Shippel (7), by Young (8) and by Alexander and Beresford (9) (Table 1). In the first two reports no definitive etiologic diagnoses were possible because oophor ectomy was not performed. In Baird and Astwood's patient, the virilizing symptoms persisted for thirteen years and through three pregnancies in addition to the pregnancy in which virilization was first noted.
