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ROBERT C. LONG, JAMES T. BRADBURY, INDUCTION AND MAINTENANCE OF DECIDUAL CHANGES WITH PROGESTERONE AND ESTROGEN, The Journal of Clinical Endocrinology & Metabolism, Volume 11, Issue 2, 1 February 1951, Pages 134–145, https://doi.org/10.1210/jcem-11-2-134
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Abstract
THE presence of the corpus luteum during pregnancy led Born, and later Fraenkel (1, 2), to investigate the influence of the corpus luteum on the implantation of the embryo. Ancel and Bouin (3) showed that the corpus luteum induced progestational changes in the endometrium of the rabbit. These findings were confirmed by other workers and climaxed by Corner and Allen (4) with the extraction of an oil-soluble substance from corpora lutea which would induce these progestational changes in the uterus of ovariectomized rabbits. They called the extracted material, progestin, a substance necessary for gestation. Since that time the crystalline hormone, progesterone, has become readily available for clinical use and favorable results have been reported in cases of threatened abortion.
In the early clinical studies, ten to twelve years ago, progesterone was available for use in doses of only 1 to 5 mg. per day. Since that time the supply of progesterone has become so plentiful that doses as high as 100 mg. per day have been used. This increase in dosage has been correlated more closely with the declining cost than with the demonstration of physiologic requirements. Corner and Allen demonstrated the minimal quantities which would bring about progestational changes in the endometrium of the rabbit and also the quantities of progesterone which would maintain pregnancy in the rabbit after ovariectomy (5).
