Response to Letter by Dolapoglu et al Free

Dear Drs. Muhammed Kizilgul, Ilimbek Beketaev and Ahmet Dolapoglu,

We have read the Letter to the Editor entitled “Could low phosphate level be the reason of high risk of hypertension in normocalcemic primary hyperparathyroidism?” by Ahmet Dolapoglu, MD, et al and thank them for their nice comments. There is no doubt that several studies have shown a relationship between low serum phosphate levels and hypertension (1–3). However, in our present study, there was no significant difference between patients with normocalcemic primary hyperparathyroidism (NPHPT) and those with normal PTH in serum phosphate (1.06 ± 0.30 vs 1.16 ± 0.19; P = .118). It is reported that that NPHPT may be due to target organ resistance to the actions of PTH (4). The resistance to PTH action on bone and kidney would result in the normal levels of serum calcium and phosphate. In addition, several studies also have confirmed that PTH plays an important role in elevating blood pressure (5–9). So we think that the elevated level of PTH rather than low phosphate level may be the reason for high risk of hypertension in NPHPT. Thanks again!

Abbreviations

 
• NPHPT

  normocalcemic primary hyperparathyroidism.

References