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Bibian van der Voorn, Jan M. Wit, Sylvia M. van der Pal, Joost Rotteveel, Martijn J. J. Finken, Antenatal Glucocorticoid Treatment and Polymorphisms of the Glucocorticoid and Mineralocorticoid Receptors are Associated with IQ and Behavior in Young Adults Born Very Preterm, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 2, 1 February 2015, Pages 500–507, https://doi.org/10.1210/jc.2014-2843
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Abstract
Preterm survivors exhibit neurodevelopmental impairments. Whether this association is influenced by antenatal glucocorticoid treatment and glucocorticoid sensitivity is unknown.
This study aimed to study the effects of antenatal glucocorticoid treatment and glucocorticoid receptor (GR) and mineralocorticoid receptor (MR) polymorphisms on behavior and intelligence quotient (IQ).
This study was part of the 19-year follow-up of the Project On Preterm and Small-for-gestational-age birth cohort.
Multicenter study.
Three hundred forty-four 19-year-olds born very preterm (gestational age < 32 wk), of whom 71 had received betamethasone antenatally.
Single antenatal treatment course of betamethasone.
Behavior (Young Adult Self Report and Young Adult Behavior Checklist for parents) and IQ (digital Multicultural Capacity Test-intermediate level).
Data were analyzed by linear regression and presented as regression coefficient (95% confidence interval [CI]).
Sex ratio, GR (R23K; N363S) and MR (−2G/C; I180V) genotypes were equally distributed between treated and nontreated subjects. Independent of treatment, R23K carriers had improved IQ scores (β 9.3; 95% CI, 3.4 to 15.1) and a tendency toward more favorable total problem behavior scores (β −8.5; 95% CI, −17.3 to 0.2) ; −2G/C CC carriers had poorer IQ scores (β −6.2; 95% CI, −10.5 to −1.9); I180V carriers had more favorable internalizing behavior scores (β −2.0; 95% CI, −3.9 to −0.1). Antenatal glucocorticoid treatment was associated with more unfavorable behavior scores, especially internalizing behavior (β 2.4; 95% CI, 0.3 to 4.5). Interaction between GR and MR polymorphisms and antenatal glucocorticoid treatment was observed, with poorer IQ scores for exposed N363S carriers; poorer intellectual subdomain scores for exposed I180V-carriers; more favorable total problem behavior scores for exposed R23K carriers.
Genetic variations in glucocorticoid sensitivity and antenatal glucocorticoid treatment are associated with IQ and behavior in young adult preterm survivors.
