-
Views
-
Cite
Cite
Mehmet Agilli, Fevzi Nuri Aydin, Yasemin Gulcan Kurt, Tuncer Cayci, Letter to the Editor: Methodological approach to paraoxonase-1 activity in obesity complicated by obstructive sleep apnea, The Journal of Clinical Endocrinology & Metabolism, Volume 100, Issue 1, 1 January 2015, Page L11, https://doi.org/10.1210/jc.2014-4044
Close - Share Icon Share
Extract
Dear Sir: In a recent issue of the JCEM, we read with great interest the article by Yadav et al (1) entitled “Impairment of High-Density Lipoprotein Resistance to Lipid Peroxidation and Adipose Tissue Inflammation in Obesity Complicated by Obstructive Sleep Apnea” in which the investigators reported that serum paraoxonase-1 (PON-1) activity and the capacity of high-density lipoprotein to protect itself from in vitro oxidation in morbidly obese patients are impaired with the presence and increasing severity of obstructive sleep apnea. However, we wish to make some comments on PON-1, which was evaluated in their study.
PON-1 is a serum enzyme closely associated with high-density lipoprotein, as the authors said. Previous studies showed that several diseases such as chronic renal failure, inflammatory bowel diseases, psoriasis, Parkinson's disease, chronic liver disease, Alzheimer's disease, vascular dementia, rheumatoid arthritis, hyperthyroidism, endometriosis, and systemic lupus erythematosus could affect serum PON-1 activity (2, 3). The authors did not mention such contributing factors. In addition, dietary supplements such as vitamin E, vitamin C, flavonoids, iron, and zinc can alter PON-1 activity (4). Also, other factors such as alcohol intake, pregnancy, and exercise status have to be stated to provide meaningful data (2).
