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UDALL J. SALMON, SAMUEL H. GEIST, ROBERT I. WALTER, NATHAN MINTZ, THERAPEUTIC EFFECTIVENESS OF ORALLY ADMINISTERED ETHINYL ESTRADIOL, The Journal of Clinical Endocrinology & Metabolism, Volume 1, Issue 7, 1 July 1941, Pages 556–558, https://doi.org/10.1210/jcem-1-7-556
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Abstract
IT HAS BECOME increasingly more evident during the past 5 years that treatment of the menopause syndrome with estrogens is a form of substitution therapy, the need for which is perpetuated by the very administration of the hormone. Once the patient has been relieved of the distressing menopause symptoms, we have to face the problem of maintaining the therapeutic effect. Discontinuation of therapy is almost invariably followed by a recurrence of symptoms. The patient consequently requires a constant supply of estrogens to meet her physiologic needs.
To be ideal, maintenance therapy should be easily administered by the patient herself, preferably orally. In addition, because of the probability that the hormone would have to be taken for many months or years, its administration should be completely devoid of any unpleasant reactions or potential harm.
