Abstract

IN THE PAST THREE YEARS many articles have been written about the synthetic estrogen, 4-4′ dihydroxy A B diethylstilbene which is now referred to as diethylstilbestrol or more simply stilbestrol, and which was discovered by Dodds and his coworkers (1). This estrogen, differing distinctly in chemical structure from the previously known estro’ gens, has been shown to produce all the biologic effects attributed to them, such as suppression of the antuitary (2), inhibition of body growth (2), proliferation of the ductile system of the breast (3), suppression of engorgement incident to lactation (4), hyperemia, edema, and distention of the uterus (5), proliferation of the endometrium (6), vaginal cornification (7), and swelling of the sexual skin (8). It likewise presumably has the supposed carcinogenic propensities of the true estrogens (9).

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