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E. C. Hamblen, W. Kenneth Cuyler, D. V. Hirst, V. O. Horner, Effects of Contraphysiologically Administered Diethylstilbestrol on the Menstrual Cycle, The Journal of Clinical Endocrinology & Metabolism, Volume 2, Issue 6, 1 June 1942, Pages 369–372, https://doi.org/10.1210/jcem-2-6-369
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Abstract
Numerous workers have reported that the intermenstrual administration of hormonal estrogens in relatively large doses results in an ‘over-riding’ of corpus luteum function. Our group, using in this fashion moderate doses of hormonal estrogens in women with normal ovarian function, observed no depressing effects upon corpus luteum function (1).
Since the non-hormonal estrogen, diethylstilbestrol, is available at low cost, its clinical use has been widespread. Unfortunately many of its applications have been and continue to be uncritical. In view of these facts it seemed worth while to investigate the effects of the contra-physiologic use of moderately small doses of diethylstilbestrol in women with normal ovarian function. The present communication deals with this investigation.
Thirteen patients in whom episodes of bleeding occurred from a progestational endometrium were chosen for these studies. Their ages ranged from 18 to 32 years and averaged 25.5 years.
Diethylstilbestrol was administered orally in daily amounts ranging from 1 to 6 mg.
