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FRED ELMADJIAN, EDWIN T. LAMSON, HARRY FREEMAN, RUDOLPH NERI, LOIS VARJABEDIAN, EXCRETION OF EPINEPHRINE AND NOREPINEPHRINE AFTER ADMINISTRATION OF INSULIN AND METHACHOLINE, The Journal of Clinical Endocrinology & Metabolism, Volume 16, Issue 7, 1 July 1956, Pages 876–886, https://doi.org/10.1210/jcem-16-7-876
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Hypoglycemia and hypotension are known to cause stimulation of the sympathico-adrenal system (1). Using insulin as the hypoglycemic agent and methacholine (Mecholyl®) as the hypotensive drug, a study was undertaken to evaluate the sympathico-adrenal response of normal male subjects by measuring the excretion of epinephrine (E) and norepinephrine (NE). In the infusion experiments with E and NE, graded doses were used. Control experiments with physiologic saline were run for thirty minutes when estimations of the excretion rate of catechol amines were made. The results of the latter experiments and those previously published on adrenalectomized subjects (2) were used for evaluation of the nature and quantity of the catechol amines secreted after the administration of the insulin and methacholine. Blood pressure and pulse rate were determined in all experiments.
