... Pathophysiology Research England Policy Support Grant Atrial fibrillation (AF) is the most common cardiac arrhythmia, with prevalence expected to rise exponentially within an ageing population. ¹ The presence of AF is associated with increased risk for cardio-/cerebrovascular mortality...

... Background Orthostatic hypotension (OH) is an important differential diagnosis in unexplained syncope. Neurogenic OH (nOH) has been postulated to differ from non-neurogenic OH (non-nOH), yet pathophysiological differences are largely unexplored. We aimed to investigate etiology and tilt table test (TTT...

... patients were collected at the central lab of the UMCG. All collected blood samples were centrifuged for 10 min at 2000 g. The serum was stored in 500 µL vials at −20°C, prior to central storage at −80°C. Cardiac amyloidosis ATTR wild-type HFpEF HFmrEF Biomarker Pathophysiology Time of primary review...

... Heart Rhythm Society (LAHRS) to contribute to the evolution of the AtCM concept. Atrium Cardiomyopathy Atrial fibrillation Pathophysiology Fibrosis Stroke Mechanisms 1. Background, definition and classification 2. Important recent basic mechanistic insights  2.1. Early-onset atrial...

... Vavlukis Despite past successes and collaborations with various ESC bodies, the WG-CPM recognizes the significant challenges in both applied and experimental coronary pathophysiology. Looking ahead, the WG-CPM is dedicated to addressing pivotal research and applied questions in coronary pathophysiology...

...:https://dbpia.nl.go.kr/pages/standard-publication-reuse-rights ) Abstract Understanding of the pathophysiology of heart failure with preserved ejection fraction (HFpEF) has advanced rapidly over the past two decades. Currently, HFpEF is recognized as a heterogeneous syndrome, and there is a growing movement towards...

... of the pathophysiology of LV hypertrophy and the applied surgical large animal models that currently better mimic the condition. Cardiac Hypertrophy Cardiac pathophysiology Cardiac cell populations Hypertrophic cardiomyocyte Cardiomyocyte nucleation Cardiac metabolism Cardiac homeostasis Cardiac contractile...

... haematopoiesis of indeterminate potential Clonal haematopoiesis Pathophysiology Cardiac remodelling Inflammation Genome Opinion See the editorial comment for this article ‘Clonal haematopoiesis and cardiac arrythmias: rhythm-altering mutations', by M.A. Zuriaga et al., https://doi.org/10.1093...

...Carol Ann Remme; Jordi Heijman; Ana M Gomez; Antonio Zaza; Katja E Odening Basic electrophysiology Translational electrophysiology Atrial fibrillation Ventricular arrhythmias Sudden cardiac death Ion channels Pathophysiology Genetics Modelling Several manuscripts investigated...

... pathophysiology. Autoantibodies (AAs) targeting angiotensin-II receptor type 1 (AT1R) and endothelin-1 receptor type A (ETAR) have known detrimental effects on endothelial function. We investigated the prevalence of these AAs in SCAD-affected female patients. Methods and results Female patients diagnosed...

... lean individuals. Pathophysiology involves lipotoxicity, hepatic immune disturbances accompanied by hepatic insulin resistance, a gut dysbiosis, and commonly hepatic and systemic insulin resistance defining this disorder a prototypic systemic metabolic disorder. Not surprisingly many affected patients...

... is very similar to the proposed mechanisms of influenza-associated MI. ⁵⁵ Thus, the pathophysiological nature of influenza virus infection is likely not unique in causing MI. Finally, similar to influenza vaccination, S. pneumoniae vaccination has also been demonstrated to decrease...

...%. Patients with LVEF between 41 and 49% are defined as having HF with mildly reduced ejection fraction (HFmrEF). These phenotypes, particularly HFrEF and HFpEF have varying underlying aetiologies and pathophysiology. Amongst patients with HFrEF, the overactivation of the neurohormonal pathway is the most...

...F Zwanenburg; J C Van Munsteren; L J Wisse; M C De Ruiter; M C Haak; M R M Jongbloed Pathophysiology and Mechanisms Abstract Background Foetal aortic stenosis (AS) is a challenging congenital heart disease considering its potential to progress during the course of pregnancy. Especially...

...Z Iskandar; M Dodd; G Stuart; M Caputo; T Clayton; C Chin; J Gibb; A Child; X Y Jin; M Flather; J T J Huang; A M Choy Pathophysiology and Mechanisms Abstract Background Marfan syndrome (MFS) is an autosomal dominant connective tissue disorder caused by mutations in the Fibrillin1 gene (FBN1...

... Disease, Pathophysiology and Mechanisms Phenotypic characterization of rabbit model for aortic valve stenosis: a novel medial calci cation paradigm N. Anousakis-Vlachochristou1, M. Mavroidis2, M. Makridakis2, A. Miliou1, G. Kontostathi2, A. Agapaki2, E. Mouchtouri2, L. Zigouri2, G. Konstantinou1, E...

...B P T Kruithof; A L Van Wijngaarden; B Mousavi Gourabi; M Palmen; N Ajmone Marsan 1562 Valvular, Myocardial, Pericardial, Pulmonary, Congenital Heart Disease Valvular Heart Disease, Pathophysiology and Mechanisms Superimposed tissue formation in human aortic valve disease: differences between...

... worse in-hospital AEs and mortality. Funding Acknowledgement Type of funding sources: None. Anatomy of atrial branches Involvement of atrial branches Pathophysiology and Mechanisms 418 Arrhythmias and Device Therapy Atrial Fibrillation (AF), Pathophysiology and Mechanisms Early vs late...

...A Chernova; S Nikulina; D Nikulin Diseases of the Aorta, Peripheral Vascular Disease, Stroke Stroke, Pathophysiology and Mechanisms 2051 Association of rs10507391 polymorphism with the development of acute cerebrovascular event A. Chernova, S. Nikulina, D. Nikulin Prof. V.F. Voino-Yasenetsky...

...A Chernova; S Nikulina; D Nikulin Pathophysiology and Mechanisms Abstract Purpose To study SNP rs11196288 (A> G) with development of Acute Cerebrovascular Event in the patients with cardiovascular pathology and risk factors of its development who are representatives of the east Siberian...