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Book cover for The ESC Textbook of Intensive and Acute Cardiovascular Care (2 edn) The ESC Textbook of Intensive and Acute Cardiovascular Care (2 edn)

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Update:

The current ESC STEMI guidelines recommend a half-dose of tenecteplase in patients above 75 years of age (IIaB recommendation), based on ...More

Update:

The current ESC STEMI guidelines recommend a half-dose of tenecteplase in patients above 75 years of age (IIaB recommendation), based on results of the STREAM trial.

The GEMINI-ACS-1 trial showed that low-dose rivaroxaban with either clopidogrel or ticagrelor but without aspirin was not superior to conventional dual antiplatelet therapy in patients with an acute coronary syndrome. Major bleeding complications were similar with both antithrombotic strategies.

The REG1 system, which combines the factor IXa antagonist pegnivacogin and its antagonist anivamersen, was not shown to be superior to bivalirudin in stable and unstable patients undergoing PCI in the REGULATE-PCI study, which was stopped prematurely because of serious allergic reactions to REG1.

The ATLANTIC trial showed that prehospital administration of ticagrelor is safe while not improving indices of coronary reperfusion before primary PCI.

Three recent large clinical trials (MATRIX, HEAT-PCI, and VALIDATE-SWEDEHEART) compared bivalirudin to monotherapy UFH (without routine GPI use), and showed no benefit of bivalirudin, neither in ischemic risk or bleeding risk, in contrast to older studies comparing bivalirudin to UFH with routine GPI use.

Disclaimer
Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always … More Oxford University Press makes no representation, express or implied, that the drug dosages in this book are correct. Readers must therefore always check the product information and clinical procedures with the most up to date published product information and data sheets provided by the manufacturers and the most recent codes of conduct and safety regulations. The authors and the publishers do not accept responsibility or legal liability for any errors in the text or for the misuse or misapplication of material in this work. Except where otherwise stated, drug dosages and recommendations are for the non-pregnant adult who is not breastfeeding.
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