Volume 149, Issue 5, 1 May 2008

News and Views

GPR119: “Double-Dipping” for Better Glycemic Control

L. Lauffer and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2035–2037, https://doi.org/10.1210/en.2008-0182

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Insulin-Like Growth Factor Binding Protein-2: A Novel Regulator of Skeletal Gender Differences?

Sundeep Khosla

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2048–2050, https://doi.org/10.1210/en.2008-0174

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Diabetes - Insulin - Glucagon - Gastrointestinal

A Role for Intestinal Endocrine Cell-Expressed G Protein-Coupled Receptor 119 in Glycemic Control by Enhancing Glucagon-Like Peptide-1 and Glucose-Dependent Insulinotropic Peptide Release

Zhi-Liang Chu and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2038–2047, https://doi.org/10.1210/en.2007-0966

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Insulin Stimulates Primary β-Cell Proliferation via Raf-1 Kinase

Jennifer L. Beith and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2251–2260, https://doi.org/10.1210/en.2007-1557

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Cross Talk between the Insulin and Wnt Signaling Pathways: Evidence from Intestinal Endocrine L Cells

Fenghua Yi and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2341–2351, https://doi.org/10.1210/en.2007-1142

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Trauma and Hemorrhage-Induced Acute Hepatic Insulin Resistance: Dominant Role of Tumor Necrosis Factor-α

Jie Xu and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2369–2382, https://doi.org/10.1210/en.2007-0922

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Protein Kinase C-ζ Phosphorylates Insulin Receptor Substrate-1, -3, and -4 But Not -2: Isoform Specific Determinants of Specificity in Insulin Signaling

Sihoon Lee and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2451–2458, https://doi.org/10.1210/en.2007-1595

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Dual Effect of Cell-Cell Contact Disruption on Cytosolic Calcium and Insulin Secretion

Fabienne Jaques and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2494–2505, https://doi.org/10.1210/en.2007-0974

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Growth Factors - Cytokines

Gender-Specific Changes in Bone Turnover and Skeletal Architecture in Igfbp-2-Null Mice

V. E. DeMambro and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2051–2061, https://doi.org/10.1210/en.2007-1068

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The Antiinflammatory Cytokine Interleukin-1 Receptor Antagonist Protects from High-Fat Diet-Induced Hyperglycemia

Nadine S. Sauter and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2208–2218, https://doi.org/10.1210/en.2007-1059

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Transcriptional Activation of Signal Transducer and Activator of Transcription (STAT) 3 and STAT5B Partially Mediate Homeobox A1-Stimulated Oncogenic Transformation of the Immortalized Human Mammary Epithelial Cell

Kumarasamypet M. Mohankumar and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2219–2229, https://doi.org/10.1210/en.2007-1320

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Energy Balance - Obesity

The Obesity Gene, FTO, Is of Ancient Origin, Up-Regulated during Food Deprivation and Expressed in Neurons of Feeding-Related Nuclei of the Brain

Robert Fredriksson and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2062–2071, https://doi.org/10.1210/en.2007-1457

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Peroxisome Proliferator-Activated Receptor-γ-Mediated Positive Energy Balance in the Rat Is Associated with Reduced Sympathetic Drive to Adipose Tissues and Thyroid Status

William T. Festuccia and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2121–2130, https://doi.org/10.1210/en.2007-1553

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Selective Loss of Leptin Receptors in the Ventromedial Hypothalamic Nucleus Results in Increased Adiposity and a Metabolic Syndrome

Nathan C. Bingham and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2138–2148, https://doi.org/10.1210/en.2007-1200

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Adverse Adipose Phenotype and Hyperinsulinemia in Gravid Mice Deficient in Placental Growth Factor

Bianca Hemmeryckx and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2176–2183, https://doi.org/10.1210/en.2007-1272

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Plasma Adiponectin Complexes Have Distinct Biochemical Characteristics

Todd Schraw and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2270–2282, https://doi.org/10.1210/en.2007-1561

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Hyperleptinemia without Obesity in Male Mice Lacking Androgen Receptor in Adipose Tissue

I-Chen Yu and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2361–2368, https://doi.org/10.1210/en.2007-0516

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Severe Obesity and Insulin Resistance due to Deletion of the Maternal G_sα Allele Is Reversed by Paternal Deletion of the G_sα Imprint Control Region

Tao Xie and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2443–2450, https://doi.org/10.1210/en.2007-1458

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Metabolic Remodeling in Adipocytes Promotes Ciliary Neurotrophic Factor-Mediated Fat Loss in Obesity

Seamus Crowe and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2546–2556, https://doi.org/10.1210/en.2007-1447

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Increased Energy Expenditure Contributes More to the Body Weight-Reducing Effect of Rimonabant than Reduced Food Intake in Candy-Fed Wistar Rats

Andreas W. Herling and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2557–2566, https://doi.org/10.1210/en.2007-1515

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Lack of Hexose-6-Phosphate Dehydrogenase Impairs Lipid Mobilization from Mouse Adipose Tissue

Iwona J. Bujalska and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2584–2591, https://doi.org/10.1210/en.2007-1705

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Reproduction - Development

Relaxin Acts on Stromal Cells to Promote Epithelial and Stromal Proliferation and Inhibit Apoptosis in the Mouse Cervix and Vagina

LiJuan Yao and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2072–2079, https://doi.org/10.1210/en.2007-1176

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Positive Regulation of Steroidogenic Acute Regulatory Protein Gene Expression through the Interaction between Dlx and GATA-4 for Testicular Steroidogenesis

Hisayo Nishida and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2090–2097, https://doi.org/10.1210/en.2007-1265

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Progestin-Regulated Luminal Cell and Myoepithelial Cell-Specific Responses in Mammary Organoid Culture

Sandra Z. Haslam and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2098–2107, https://doi.org/10.1210/en.2007-1398

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Biochemical and Structural Characterization of Apolipoprotein A-I Binding Protein, a Novel Phosphoprotein with a Potential Role in Sperm Capacitation

Kula N. Jha and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2108–2120, https://doi.org/10.1210/en.2007-0582

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Epidermal Growth Factor Abrogates Hypoxia-Induced Apoptosis in Cultured Human Trophoblasts through Phosphorylation of BAD Serine 112

Rachel G. Humphrey and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2131–2137, https://doi.org/10.1210/en.2007-1253

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DEAD-Box Protein-103 (DP103, Ddx20) Is Essential for Early Embryonic Development and Modulates Ovarian Morphology and Function

Jean-François Mouillet and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2168–2175, https://doi.org/10.1210/en.2007-1237

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Premenstrual Regulation of the Pro-Angiogenic Factor CYR61 in Human Endometrium

Isabella Gashaw and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2261–2269, https://doi.org/10.1210/en.2007-1568

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Polyamines Are Essential in Embryo Implantation: Expression and Function of Polyamine-Related Genes in Mouse Uterus during Peri-Implantation Period

Yue-Chao Zhao and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2325–2332, https://doi.org/10.1210/en.2007-1420

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Activin-A in Myometrium: Characterization of the Actions on Myometrial Cells

Pasquapina Ciarmela and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2506–2516, https://doi.org/10.1210/en.2007-0692

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Effect of Glutathione Depletion on Leydig Cell Steroidogenesis in Young and Old Brown Norway Rats

Haolin Chen and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2612–2619, https://doi.org/10.1210/en.2007-1245

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Peroxisome Proliferator-Activated Receptor-γ Agonist Rosiglitazone Reverses the Adverse Effects of Diet-Induced Obesity on Oocyte Quality

Cadence E. Minge and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2646–2656, https://doi.org/10.1210/en.2007-1570

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Pathways Leading to Phosphorylation of P450c17 and to the Posttranslational Regulation of Androgen Biosynthesis

Meng Kian Tee and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2667–2677, https://doi.org/10.1210/en.2007-1527

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Glucocorticoids - CRH - ACTH - Adrenal

LGD-5552, an Antiinflammatory Glucocorticoid Receptor Ligand with Reduced Side Effects, in Vivo

Francisco J. López and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2080–2089, https://doi.org/10.1210/en.2007-1353

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Mitogen-Activated Protein Kinase Contributes to Lipopolysaccharide-Induced Activation of Corticotropin-Releasing Hormone Synthesizing Neurons in the Hypothalamic Paraventricular Nucleus

Praful S. Singru and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2283–2292, https://doi.org/10.1210/en.2007-1478

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Evolutionarily Conserved Glucocorticoid Regulation of Corticotropin-Releasing Factor Expression

Meng Yao and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2352–2360, https://doi.org/10.1210/en.2007-1551

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Obesity and Hypertriglyceridemia Produce Cognitive Impairment

Susan A. Farr and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2628–2636, https://doi.org/10.1210/en.2007-1722

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Glucocorticoid (GC)-Mediated Down-Regulation of Urokinase Plasminogen Activator Expression via the Serum and GC Regulated Kinase-1/Forkhead Box O3a Pathway

Travis Pew and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2637–2645, https://doi.org/10.1210/en.2007-1096

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Neuroendocrinology

Interplay between the Endocannabinoid System and GnRH-I in the Forebrain of the Anuran Amphibian Rana esculenta

Rosaria Meccariello and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2149–2158, https://doi.org/10.1210/en.2007-1357

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Proliferative and Protective Effects of Growth Hormone Secretagogues on Adult Rat Hippocampal Progenitor Cells

Inger Johansson and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2191–2199, https://doi.org/10.1210/en.2007-0733

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The Gastrointestinal Hormone Ghrelin Modulates Inhibitory Neurotransmission in Deep Laminae of Mouse Spinal Cord Dorsal Horn

Angela M. Vergnano and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2306–2312, https://doi.org/10.1210/en.2007-1164

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β₁-Adrenoceptor Expression in Rat Anterior Pituitary Gonadotrophs and in Mouse αT3-1 and LβT2 Gonadotrophic Cell Lines

Kristel Janssens and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2313–2324, https://doi.org/10.1210/en.2007-1396

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Absence of Gonadotropin-Releasing Hormone 1 and Kiss1 Activation in α-Fetoprotein Knockout Mice: Prenatal Estrogens Defeminize the Potential to Show Preovulatory Luteinizing Hormone Surges

David González-Martínez and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2333–2340, https://doi.org/10.1210/en.2007-1422

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β₁-Adrenoceptors in Rat Anterior Pituitary May Be Constitutively Active. Inverse Agonism of CGP 20712A on Basal 3′,5′-Cyclic Adenosine 5′-Monophosphate Levels

Kristel Janssens and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2391–2402, https://doi.org/10.1210/en.2007-1397

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Ovarian Steroids Stimulate Adenosine Triphosphate-Sensitive Potassium (K_ATP) Channel Subunit Gene Expression and Confer Responsiveness of the Gonadotropin-Releasing Hormone Pulse Generator to K_ATP Channel Modulation

Wenyu Huang and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2423–2432, https://doi.org/10.1210/en.2007-0830

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Gonadotropin-Releasing Hormone (GnRH) Activates the M-Current in GnRH Neurons: An Autoregulatory Negative Feedback Mechanism?

Chun Xu and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2459–2466, https://doi.org/10.1210/en.2007-1178

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Identification of KiSS-1 Product Kisspeptin and Steroid-Sensitive Sexually Dimorphic Kisspeptin Neurons in Medaka (Oryzias latipes)

Shinji Kanda and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2467–2476, https://doi.org/10.1210/en.2007-1503

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Induction of Type 2 Iodothyronine Deiodinase in the Mediobasal Hypothalamus by Bacterial Lipopolysaccharide: Role of Corticosterone

Edith Sánchez and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2484–2493, https://doi.org/10.1210/en.2007-1697

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Control of the Hypothalamo-Pituitary-Adrenal Axis in the Neonatal Period: Adrenocorticotropin and Corticosterone Stress Responses Dissociate in Vasopressin-Deficient Brattleboro Rats

Dóra Zelena and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2576–2583, https://doi.org/10.1210/en.2007-1537

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Selective Estrogen Receptor Modulators Differentially Regulate Alzheimer-Like Changes in Female 3xTg-AD Mice

Jenna C. Carroll and Christian J. Pike

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2607–2611, https://doi.org/10.1210/en.2007-1346

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General Endocrinology

Rapid Changes in Anterior Pituitary Cell Phenotypes in Male and Female Mice after Acute Cold Stress

Laura Senovilla and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2159–2167, https://doi.org/10.1210/en.2007-1030

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Regulation of SREBP1c Gene Expression in Skeletal Muscle: Role of Retinoid X Receptor/Liver X Receptor and Forkhead-O1 Transcription Factor

Yasutomi Kamei and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2293–2305, https://doi.org/10.1210/en.2007-1461

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Bone Growth and Turnover in Progesterone Receptor Knockout Mice

David J. Rickard and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2383–2390, https://doi.org/10.1210/en.2007-1247

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The Murine Stanniocalcin 2 Gene Is a Negative Regulator of Postnatal Growth

Andy C.-M. Chang and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2403–2410, https://doi.org/10.1210/en.2007-1219

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Low Doses of Insulin-Like Growth Factor I Improve Insulin Resistance, Lipid Metabolism, and Oxidative Damage in Aging Rats

María García-Fernández and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2433–2442, https://doi.org/10.1210/en.2007-1190

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Relaxation of Androgens on Rat Thoracic Aorta: Testosterone Concentration Dependent Agonist/Antagonist l-Type Ca²⁺ Channel Activity, and 5β-Dihydrotestosterone Restricted to l-Type Ca²⁺ Channel Blockade

Luis M. Montaño and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2517–2526, https://doi.org/10.1210/en.2007-1288

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Dehydroepiandrosterone and Corticosterone Are Regulated by Season and Acute Stress in a Wild Songbird: Jugular Versus Brachial Plasma

Amy E. M. Newman and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2537–2545, https://doi.org/10.1210/en.2007-1363

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Low Doses of Insulin-Like Growth Factor-I Induce Mitochondrial Protection in Aging Rats

Juan E. Puche and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2620–2627, https://doi.org/10.1210/en.2007-1563

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Implication of the Endocannabinoid System in the Locomotor Hyperactivity Associated with Congenital Hypothyroidism

Teresa Asúa and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2657–2666, https://doi.org/10.1210/en.2007-1586

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Intracoronary Genistein Acutely Increases Coronary Blood Flow in Anesthetized Pigs through β-Adrenergic Mediated Nitric Oxide Release and Estrogenic Receptors

Elena Grossini and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2678–2687, https://doi.org/10.1210/en.2007-1361

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Thyroid - TRH -TSH

Genotype-Phenotype Relationship in Patients with Mutations in Thyroid Hormone Transporter MCT8

Jurgen Jansen and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2184–2190, https://doi.org/10.1210/en.2007-1475

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Thyroid Hormone Induces Hypoxia-Inducible Factor 1α Gene Expression through Thyroid Hormone Receptor β/Retinoid X Receptor α-Dependent Activation of Hepatic Leukemia Factor

Teresa Otto and Joachim Fandrey

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2241–2250, https://doi.org/10.1210/en.2007-1238

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The Balance between Oligodendrocyte and Astrocyte Production in Major White Matter Tracts Is Linearly Related to Serum Total Thyroxine

David S. Sharlin and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2527–2536, https://doi.org/10.1210/en.2007-1431

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Growth Hormone - Somatostatin - GRH

Endothelin-Converting Enzyme-1 Degrades Internalized Somatostatin-14

Dirk Roosterman and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2200–2207, https://doi.org/10.1210/en.2007-1628

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Growth Hormone Regulation of Insulin-Like Growth Factor-I Gene Expression May Be Mediated by Multiple Distal Signal Transducer and Activator of Transcription 5 Binding Sites

Satyanaryana Eleswarapu and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2230–2240, https://doi.org/10.1210/en.2007-1344

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Calcium Regulating Hormones

Paralogous Vitamin D Receptors in Teleosts: Transition of Nuclear Receptor Function

Deanna L. Howarth and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2411–2422, https://doi.org/10.1210/en.2007-1256

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Renal - Cardiac - Vascular

Microribonucleic Acid-21 Increases Aldosterone Secretion and Proliferation in H295R Human Adrenocortical Cells

Damian G. Romero and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2477–2483, https://doi.org/10.1210/en.2007-1686

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Cancer - Oncogenes

The Nutritional Flavanone Naringenin Triggers Antiestrogenic Effects by Regulating Estrogen Receptor α-Palmitoylation

Paola Galluzzo and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2567–2575, https://doi.org/10.1210/en.2007-1173

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Cancer - Oncogenes

Identification of Cyclic Adenosine 3′,5′-Monophosphate Response Element Modulator as an Activator of the Human Sodium/Iodide Symporter Upstream Enhancer

Mike S. Fenton and others

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2592–2606, https://doi.org/10.1210/en.2007-1390

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Research Resources

Endocrine-Related Resources from the National Institutes of Health

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2688–2691, https://doi.org/10.1210/endo.149.5.9999

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National Hormone & Peptide Program (NHPP): New Recombinant Hormones, Hypothalamic Peptides, Natural Hormones, New Antisera, & Expanded Hormone Assay Services Available

Endocrinology, Volume 149, Issue 5, 1 May 2008, Pages 2692–2694, https://doi.org/10.1210/endo.149.5.0134

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