Hypocalcemia following gastrin administrationoccurs in thyroparathyroidectomized(TPTX) as well as thyroid intact rats. Hypophosphatemiadoes not accompany the hypocalcemiainduced by gastrin. These data suggest that amechanism other than release of calcitonin from thethyroid gland may be involved in this response inthe rat.

Neither adrenalectomy, nephrectomy, nor excisionof the pancreas and small and large intestinealtered the hypocalcemic response to gastrin. Gastrectomy,however, eliminated all hypocalcemiafollowing administration of this polypeptide in boththyroid intact and TPTX rats. Removal of theantrum of the stomach did not influence thehypocalcemic response to gastrin. Resection of theproximal 75% of the stomach, however, inhibitedthe hypocalcemic response to gastrin as did totalgastrectomy. Thus, in the rat, the proximal stomachappears to play an important role in mediating thisresponse (Endocrinology96: 1217, 1975)

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