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S. MITCHELL HARMAN, JEAN-PIERRE LOUVET, GRIFF T. ROSS, Interaction of Estrogen and Gonadotrophins on Follicular Atresia, Endocrinology, Volume 96, Issue 5, 1 May 1975, Pages 1145–1152, https://doi.org/10.1210/endo-96-5-1145
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We have investigated follicular atresia by giving hypophysectomized immature female rats (HIFR) diethylstibestrol or gonadotrophins with and without the chemical antiestrogen CI-628, making total counts of normal and atretic follicles greater than 125 μM in diameter, and using a simple model to analyze data. Our results show an anti-atretic effect of estrogen, independent of its well documented mitogenic effect on preantral follicles. We have also shown that CI-628 acts as an anti-estrogen to block follicular proliferation, while acting as an estrogen to inhibit atresia. In addition, we have observed an increase in atresia caused by gonadotrophins, in opposition to their estrogen-mediated positive effect on follicular growth. (Endocrinology96: 1145, 1975)