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W. D. ODELL, R. S. SWERDLOFF, J. BAIN, F. WOLLESEN, P. K. GROVER, The Effect of Sexual Maturation on Testicular Response to LH Stimulation of Testosterone Secretion in the Intact Rat, Endocrinology, Volume 95, Issue 5, 1 November 1974, Pages 1380–1384, https://doi.org/10.1210/endo-95-5-1380
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Varying doses (1, 3, 10 and 30 µg⁄100 g body wt) of NIH-LH-B7 were administered intraperitoneally to groups of male rats, 10, 21, 41 and 62 days of age. Serum testosterone (T) was quantified adioimmunoassay 1 hr later, the time when the LH-induced testosterone rise was maximal. The 1 µg does did not significantly increase serum T concentrations over those in saline-injected controls. For the higher doses of LH, an age-related response was found. One hr after LH, the testosterone concentration was least in the 10-day-old animals, greater in the 21-day-old animals, and greatest in the 42 and 62-day-old animals; the latter were indistinguishable. Given as percent increase to 10 µg LH⁄100 g body wt,the values were as follows: 10 days, 213 ± 12%; 21 days, 543 ± 48%;41 days,787 ± 121%; and 62 days, 755 ± 207%. The responseto 30 µg LH⁄100 g body wt was 10 days, 214 ± 14%; 21 days, 602 ± 48%; 41 days, 1673 ± 146%; and 62 days, 1570 ± 130%. These studies demonstrate for the first time that the response to LH stimulation of testosterone increases with age in the intact male rat and offers additional support for the hypothesis that changing testicular responsiveness to LH may be a factor in sexual maturation (Endocrinology95: 1380, 1974)
