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W. Y. CHAN, MARGITTA WAHRENBURG, Inactivation of Oxytocin and Deamino-oxytocin by Nonpregnant and Pregnant Rat Uterine Homogenates, Endocrinology, Volume 82, Issue 3, 1 March 1968, Pages 475–479, https://doi.org/10.1210/endo-82-3-475
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Homogenates of rat uteri had the ability to inactivate oxytocin and deaminooxytocin. There was an increase of this activity in uteri during pregnancy. In homogenates of estrous rat uteri the oxytocin inactivation curve was linear, whereas the deamino-oxytocin inactivation curve was not. In pregnant uteri, the increase in oxytocin inactivating activity was about 40%. The increase in deamino-oxytocin inactivating activity was small and statistically not significant. The results suggest that the inactivation of oxytocin was enzymic in nature and that a different enzyme or some other mechanism was probably responsible for the inactivation of deamino-oxytocin. It was further found that oxytocin was bound by tissue protein in the homogenate. Deamino-oxytocin did not bind with the tissue protein under identical conditions. (Endocrinology82: 475, 1968)