-
Views
-
Cite
Cite
PETER V. TISHLER, Effect of Thyroxine Administered in Vitro and in Vivo on the Succinoxidase and Malic Dehydrogenase Reactions of Frog Myocardium, Endocrinology, Volume 72, Issue 5, 1 May 1963, Pages 673–676, https://doi.org/10.1210/endo-72-5-673
- Share Icon Share
The effect of thyroxine (T4) on oxidation of succinate and of malate by frog myocardial homogenates was assessed following in vivo or in vitro administration of the hormone. In vitro, T4 enhanced the oxidation of succinate and inhibited oxidation of malate, a response similar to that observed in the myocardium of the rat. Following in vivo administration of T4, no enhancement of succinate oxidation could be demonstrated, and malate oxidation was slightly stimulated. The significance of the succinoxidase response as a manifestation of the action of thyroid hormone and its relationship to the deiodination of T4 are discussed.