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N. S. HALMI, D. K. GRANNER, D. J. DOUGHMAN, B. D. SMITH, RESPONSE OF THE THYROIDAL IODIDE PUMP AND THYROID WEIGHT TO GOITROGENS IN RATS FED LOW OR HIGH IODINE DIETS, Endocrinology, Volume 65, Issue 4, 1 October 1959, Pages 607–613, https://doi.org/10.1210/endo-65-4-607
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Abstract
Rats fed a diet rich in iodine and killed in groups 1–23 days after the initiation of goitrogenic regimens (methylmercaptoimidazole in the drinking water or propylthiouracil injected subcutaneously) showed a prompt and progressive rise in the thyroid-serum radioiodide concentration ratio (T/S) and the thyroidal radioiodide space; goiter developed more slowly. In rats on a low iodine diet treated with the same goitrogens the initially high T/S was significantly diminished during the first week of antithyroid treatment and even the thyroidal radioiodide space showed transient contraction; the goitrogenic effect of propylthiouracil manifested itself earlier than in the rats on the high iodine diet. No significant depression of the. T/S was achieved when rats fed the low iodine regimen were injected with thyrotrophin; thyroidal radioiodide space and thyroid size increased. The same dose of hormone given to rats on the high iodine diet markedly raised the T/S and expanded the thyroidal radioiodide space, but it had only a statistically equivocal effect on thyroid weight. Hypophysectomized rats maintained on the low iodine diet and injected with thyrotrophin showed high T/S values which were further enhanced by short term treatment with propylthiouracil; the size of the thyroids was not affected by the goitrogen and their radioiodide space therefore increased to the same extent as the T/S. The paradoxical effect of goitrogens on the thyroidal iodide pump of iodine deficient intact rats is discussed.
