Abstract

THE increasing therapeutic use of long-acting sex hormone preparations seems to indicate that bioassay methods based on the duration of action of such preparations might be of value. The introduction into therapeutics of poly-estradiol phosphate (P.E.P.), a water soluble high molecular weight polyester of phosphoric acid and estradiol-17β (1, 2) led to the need of a method of comparing the prolonged estrogenic effect of various P.E.P.-preparations. The present paper reports on a method of bioassay based on the duration of vaginal cornification in spayed mice.

This content is only available as a PDF.
You do not currently have access to this article.