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R. C. GOLDBERG, I. L. CHAIKOFF, A SIMPLIFIED PROCEDURE FOR THYROIDECTOMY OF THE NEW-BORN RAT WITHOUT CONCOMITANT PARATHYROIDECTOMY, Endocrinology, Volume 45, Issue 1, 1 July 1949, Pages 64–70, https://doi.org/10.1210/endo-45-1-64
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Abstract
Surgical thyroidectomy of the very young rat is difficult because of the size of the animal and the condition of its tissues. The operation has been performed successfully, however, by two groups of workers. Salmon (1936), who first demonstrated the feasibility of surgical excision of the thyroid gland, along with the parathyroid, in this animal as early as one or two days after its birth, employed cold anesthesia and observed survival for longer than one week in about 36 per cent of the operated rats. Scow and Simpson (1945), who employed a similar technique, with even lower temperatures for anesthetic purposes, showed survival of less than seven per cent of their totally thyroidectomized rats. In view of these difficulties, we wish to report a simplified procedure for discrete total thyroidectomy of the new-born rat without recourse to the more complicated surgical technique.