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H. S. RUBINSTEIN, THE EFFECT OF THE ANTERIOR PITUITARY-LIKE HORMONE ON SPERMATOGENESIS IN THE HUMAN, Endocrinology, Volume 23, Issue 1, 1 July 1938, Pages 75–78, https://doi.org/10.1210/endo-23-1-75
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Abstract
Because of conflicting reports concerning the effect of the anterior pituitary-like hormone on spermatogenesis (1, 2) it appeared timely to examine this question more critically.
For this purpose 6 healthy adult human males were chosen, from each of whom a number of control spermatic specimens were studied. It was found that, after one ejaculation, the sperm count gradually increased through a period of 6 or 7 days, when the number became more or less stationary. The wide variation in spermatozoal output was taken into consideration, and therefore 2 counts were listed for each individual, a 1-day and a 6- or 7-day control, depending on the interval in days since a prior ejaculation.
Each subject was then given 3 intramuscular injections of the watersoluble fraction of pregnancy urine weekly, beginning with 100 r.u. The dosage was quickly increased to 300 and 400 r.u., SO that after 2 weeks a total of 1000 r.u. per week was reached. Dosage was maintained at this level throughout the periods of injections, which lasted with different individuals from 5 to 9 weeks.
