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BRUNO SOLOMONICA, RAPHAEL KURZROK, THE INFLUENCE OF ENDOCRINE GLAND PREPARATIONS ON ALLERGIC REACTIONS. (ANTERIOR PITUITARY EXTRACT, PREGNANCY URINE EXTRACT, FOLLICULAR HORMONE), Endocrinology, Volume 20, Issue 2, 1 March 1936, Pages 171–173, https://doi.org/10.1210/endo-20-2-171
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Abstract
Attention has been called to the influence of the endocrine system on anaphylactic reactions by the experiments of Lanzenberg and Kepinow (1). They showed that thyroidectomy lessened the anaphylactic reactions of guinea pigs sensitized and shocked with horse serum. Wolfram and Zwemer (2) have shown that adrenocortical extract (cortin) protected guinea pigs against anaphylactic shock, when administered a few hours prior to the injection of the shocking dose.
The present report contains data that have been arrived at from a study of the effect of anterior pituitary extract (A.P.E.), pregnancy urine extract (P.U.) and follicular hormone on anaphylactic reactions in guinea pigs. Special attention was paid to A.P.E., due to its known effects on the thyroid, gonads and adrenal glands. The effect of A.P.E. on the histology and physiology of the thyroid and the accompanying changes in the basal metabolic rate has been observed by many investigators. Friedgood (3) noted the effect of daily administration of A.P.E. on guinea pigs over varying lengths of time. These observations suggested a set of experiments in which variations in anaphylactic reactions might be correlated with such changes in the thyroid function and basal metabolic rate. But, as will be seen later, the results of these experiments are such as not to be attributed solely to changes occurring in the thyroid. The possibility of an effect of the A.P.E. directly on allergic reactions, or indirectly through the gonads, was not overlooked. Such considerations are not taken up in this report and will be recorded in a later paper.
