-
Views
-
Cite
Cite
Irena Iankova, Carine Chavey, Cyrielle Clapé, Claude Colomer, Nathalie C. Guérineau, Nicolas Grillet, Jean-François Brunet, Jean-Sébastien Annicotte, Lluis Fajas, Regulator of G Protein Signaling-4 Controls Fatty Acid and Glucose Homeostasis, Endocrinology, Volume 149, Issue 11, 1 November 2008, Pages 5706–5712, https://doi.org/10.1210/en.2008-0717
- Share Icon Share
Circulating free fatty acids are a reflection of the balance between lipogenesis and lipolysis that takes place mainly in adipose tissue. We found that mice deficient for regulator of G protein signaling (RGS)-4 have increased circulating catecholamines, and increased free fatty acids. Consequently, RGS4−/− mice have increased concentration of circulating free fatty acids; abnormally accumulate fatty acids in liver, resulting in liver steatosis; and show a higher degree of glucose intolerance and decreased insulin secretion in pancreas. We show in this study that RGS4 controls adipose tissue lipolysis through regulation of the secretion of catecholamines by adrenal glands. RGS4 controls the balance between adipose tissue lipolysis and lipogenesis, secondary to its role in the regulation of catecholamine secretion by adrenal glands. RGS4 therefore could be a good target for the treatment of metabolic diseases.