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Ching Song, Shutsung Liao, Cholestenoic Acid Is a Naturally Occurring Ligand for Liver X Receptor α
*, Endocrinology, Volume 141, Issue 11, November 2000, Pages 4180–4184, https://doi.org/10.1210/endo.141.11.7772This work was supported by NIH grants.
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Abstract
Excessive cholesterol is eliminated from extrahepatic cells by reverse cholesterol transport, a process by which neutral sterols are transferred to extracellular acceptor lipoproteins for further transport to the liver. Another process independent of lipoproteins involves excretion of 3β-hydroxy-5-cholesten-25(R)-26-carboxylic (cholestenoic) acid, a metabolite of 27-hydroxycholesterol. Physiological concentrations of cholestenoic acid activated the nuclear receptor liver X receptor α (LXRα; NR1H3), but not other oxysterol receptors. As a ligand, cholestenoic acid modulated interaction of LXRα with the nuclear receptor coactivator Grip-1. Cholestenoic acid, therefore, may function as a signaling molecule for regulation of lipid metabolism via LXRα.