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E Redei, H Hilderbrand, F Aird, Corticotropin release inhibiting factor is encoded within prepro-TRH, Endocrinology, Volume 136, Issue 4, 1 April 1995, Pages 1813–1816, https://doi.org/10.1210/en.136.4.1813
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Abstract
Corticotropin synthesis and secretion is under negative feedback regulation by glucocorticoids. In addition a hypothalamic factor inhibiting ACTH synthesis and secretion, named corticotropin release inhibiting factor (CRIF), has been postulated but not identified. Here we report that transient transfection of a rat prepro-TRH cDNA into the mouse anterior pituitary tumor cell line AtT-20 inhibits the synthesis and secretion of both basal and CRH-stimulated ACTH. Thus, CRIF appears to be encoded by the same precursor as TRH, suggesting a coordinated regulation of pituitary-adrenal and pituitary-thyroid functions.