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Don Jefferys, John V. Funder, THYROID HORMONES AND THE ACQUISITION AND RETENTION OF BEHAVIOURAL RESPONSES, Endocrinology, Volume 125, Issue 2, 1 August 1989, Pages 1103–1105, https://doi.org/10.1210/endo-125-2-1103
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Abstract
Naive rats placed in a plexiglass cylinder for a 15 minute test period show progressive immobility, and retain the immobile response when given a 5-minute retest 24 hours later. In the present study we show that hypothyroidism markedly attenuates the acquisition of the immobile response; that this effect on acquisition is reversed 5–10 minutes after the administration of thyroxine; and that hypothyroid rats treated with a single dose of thyroxine up to 2 hours after the initial test show levels of immobility on re-test indistinguishable from intact rats.