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H. C. LEE, S. BONNER-WEIR, G. C. WEIR, J. L. LEAHY, Compensatory Adaption to Partial Pancreatectomy in the Rat, Endocrinology, Volume 124, Issue 3, 1 March 1989, Pages 1571–1575, https://doi.org/10.1210/endo-124-3-1571
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The aim of the present study was to determine if compensatory adaptions in pancreatic B-cell mass and/or function occur when B-cell mass is reduced without altering glucose tolerance. Islet mass and insulin secretory responses (both in vivo and in vitro) were assessed 19 days after a 40% pancreatectomy (Px) in 5-week-old rats. Plasma glucose and insulin values were unchanged by the 40% Px, both in the fed state and after ip glucose. Also, glucose potentiation of arginineinduced insulin secretion was fully intact when assessed with the in vitro perfused pancreas. Islet mass, assessed using pointcounting morphometrics, was 84% of the sham value, not the expected 60%. In contrast, there was no compensatory change in acinar tissue, as judged by pancreatic weight. To determine if the insulin secretory reserve capacity was reduced after the 40% Px, dexamethasone was given on days 14-18. On day 18, the Px rats were mildly hyperglycemic, but by the next day, glucose tolerance post-ip gluc se was normal, and the insulin responses to the ip glucose in vivo and arginine in vitro were identical in the dexamethasone-treated Px and sham rats.
These data show no discernible change in quantitative or qualitative B-cell secretory responses after 40% Px. A key mechanism contributing to this maintenance of normal function was regrowth of much of the excised islet tissue. (Endocrinology124: 1571-1575, 1989)
