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ALAN M. LEFCORT, DAVID G. WARD, DONALD S. GANN, Electrolytic Lesions of the Dorsal Rostral Pons Prevent Adrenocorticotropin Increases after Hemorrhage, Endocrinology, Volume 114, Issue 6, 1 June 1984, Pages 2148–2153, https://doi.org/10.1210/endo-114-6-2148
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Abstract
To determine if a discrete area of the dorsal rostral pons in the region of the locus coeruleus (LC) is essential for the reflex response of ACTH to hemorrhage, chloraloseanesthetized cats with bilateral electrolytic (11 cats) or sham (3 cats) lesions were challenged with a 15 ml/kg ∣ 3 min hemorrhage. Sequential arterial blood samples taken at −6, −3, 3, 6, 9, 15, and 21 min from hemorrhage were analyzed for ACTH content. Cats were grouped according to whether plasma ACTH increased in response to hemorrhage. Bilateral lesions in 7 cats with an area in common, which lay within the LC complex, blocked the reflex increase in plasma ACTH in response to hemorrhage which was seen in 3 sham-lesioned cats, in 3 cats with lesions that did not infringe in this region bilaterally, and in 1 cat with lesions that infringed only on the medial-ventral aspect of the LC-subcoeruleus. These findings suggest that hemodynamic information responsible for the reflex response of ACTH to hemorrhage of this magnitude passes through a discrete region of the dorsal rostral pons. (Endocrinology114: 2148, 1984)